Abstract:
This presentation was coauthored by Specialty Silicone Fabricators (SSF) and Momentive Performance Materials (MPM) and addresses the advantages of silicone vulcanization via UV light. MPM discusses the attributes of their novel formulation and compares this with more standard silicone chemistries. SSF summarizes the results of a Case Study involving active pharmaceutical ingredients (API) which were added to a Momentive LSR and cured via UV light. Drug elution profiles for UV and thermally cured test articles containing dexamethasone sodium phosphate are compared. Drug stability is confirmed using NMR technology.

We will discuss:

• Overview of UV vulcanization
• Summary of Case Study involving Active Pharmaceutical Ingredients vulcanized in silicone matrix using UV light
• Comparison of drug elution from test articles cured via UV and thermal process

Intended audience: Design Engineers, Medical Device Specifiers, Medical OEMs

About the speaker:
Mark Paulsen, Director of Business Development

Mark Paulsen serves as Director of Business Development for Specialty Silicone Fabricators. Prior to joining SSF in 2009, he spent 19 years at NuSil Technology, serving as Biomaterials Director from 1992 to 2008. Paulsen holds three patents for the development of a novel silicone elastomer used as insulation in cardiac and neurological stimulation devices. In 2004 he was recognized as one of the Top 100 Notable People in the Medical Device Industry.

Currently Paulsen and colleagues from SSF are collaborating with pharmaceutical and medical device companies on developing manufacturing platforms for the commercialization of drug-device combination products. Paulsen attended Harvard University where he studied Chemistry and currently resides in Santa Barbara, California.

Mel Toub, Application Development Manager, Momentive Performance Materials

Mel Toub currently directs Application Development for both high consistency and liquid injection molding silicone elastomers at Momentive Performance Materials. He attended Rensselaer Polytechnic Institute, where he obtained bachelors and masters degrees in Materials Engineering and an MBA. Mel has presented numerous technical papers to SAE , ACS, and the International Silicone Conference on different aspects of silicone elastomer technology and has also chaired the three day Silicone Elastomers Course at the University Of Wisconsin. He holds four patent applications in the silicone heat cured elastomer area. When not developing new silicone elastomers, Mel enjoys playing the bassoon and performs professionally in several orchestras and chamber music groups in the Upstate New York area.